A semi-synthetic glycosaminoglycan analogue inhibits and reverses Plasmodium falciparum cytoadherence

@inproceedings{Skidmore2017ASG,
  title={A semi-synthetic glycosaminoglycan analogue inhibits and reverses Plasmodium falciparum cytoadherence},
  author={Mark Skidmore and Khairul Mohd Fadzli Mustaffa and Lynsay C Cooper and Scott E. Guimond and Edwin A Yates and Alister G Craig},
  booktitle={PloS one},
  year={2017}
}
A feature of mature Plasmodium falciparum parasitized red blood cells is their ability to bind surface molecules of the microvascular endothelium via the parasite-derived surface protein Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1). This ligand is associated with the cytoadherence pathology observed in severe malaria. As pRBC treated with effective anti-malarial drugs are still able to cytoadhere, there is therefore a need to find an adjunct treatment that can inhibit and… CONTINUE READING
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