A self-setting TTCP-DCPD apatite cement for release of vancomycin.

  title={A self-setting TTCP-DCPD apatite cement for release of vancomycin.},
  author={Chiaki Hamanishi and Katsuhiko Kitamoto and Shinpei Tanaka and Makoto Otsuka and Yutaka Doi and Toshihiro Kitahashi},
  journal={Journal of biomedical materials research},
  volume={33 3},
Vancomycin (VCM), a methiciline-cefem resistant Staphylococcus aureus (MRSA)-specific antibiotic, was incorporated in a self-setting tetracalcium phosphate (TTCP)-dicalcium phosphate dihydrate (DCPD) apatite cement that hardened isothermally into a hydroxyapatite (HAP) phase with crystallinity similar to that of host bone. Effective release of VCM into PBS lasted for 2 weeks from cements containing 1% VCM and for longer than 9 weeks from cements containing 5% VCM. The rate of release of VCM… CONTINUE READING


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