A self-renewing multipotential stem cell in embryonic rat cerebral cortex

@article{Davis1994ASM,
  title={A self-renewing multipotential stem cell in embryonic rat cerebral cortex},
  author={Andrew A. Davis and Sally Temple},
  journal={Nature},
  year={1994},
  volume={372},
  pages={263-266}
}
NEUROECTODERM cells in the cortical ventricular zone generate many diverse cell types, maintain the ventricular zone during embryonic life and create another germinal layer, the subventri-cular zone, which persists into adulthood1,2. In other vertebrate tissues, including skin, intestine, blood and neural crest, stem cells are important in maintaining a germinal population and generating differentiated progeny3–6. By following the fates of single ventri-cular zone cells in culture, we show here… CONTINUE READING
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