A self-fulfilling prophecy: C-reactive protein attenuates nitric oxide production and inhibits angiogenesis.

@article{Verma2002ASP,
  title={A self-fulfilling prophecy: C-reactive protein attenuates nitric oxide production and inhibits angiogenesis.},
  author={Subodh Verma and Chao-Hung Wang and Shu-hong Li and Aaron Sean Dumont and Paul W. M. Fedak and Mitesh V. Badiwala and Bikramjit Singh Dhillon and Richard D. Weisel and R. K.-Y. Li and Donald A. G. Mickle and Duncan J Stewart},
  journal={Circulation},
  year={2002},
  volume={106 8},
  pages={913-9}
}
BACKGROUND Given the central importance of nitric oxide (NO) in the development and clinical course of cardiovascular diseases, we sought to determine whether the powerful predictive value of C-reactive protein (CRP) might be explained through an effect on NO production. METHODS AND RESULTS Endothelial cells (ECs) were incubated with recombinant CRP (0 to 100 microg/mL, 24 hours), and NO and cyclic guanosine monophosphate (cGMP) production was assessed. The effects of CRP on endothelial NO… CONTINUE READING

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