A self-avoidance mechanism in patterning of the urinary collecting duct tree

@inproceedings{Davies2014ASM,
  title={A self-avoidance mechanism in patterning of the urinary collecting duct tree},
  author={Jamie A. Davies and Peter Hohenstein and C-Hong Chang and Rachel L. Berry},
  booktitle={BMC Developmental Biology},
  year={2014}
}
Glandular organs require the development of a correctly patterned epithelial tree. These arise by iterative branching: early branches have a stereotyped anatomy, while subsequent branching is more flexible, branches spacing out to avoid entanglement. Previous studies have suggested different genetic programs are responsible for these two classes of branches. Here, working with the urinary collecting duct tree of mouse kidneys, we show that the transition from the initial, stereotyped, wide… CONTINUE READING
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