• Medicine
  • Published in
    Biochemical and biophysical…
    2006

A self-assembled quantum dot probe for detecting beta-lactamase activity.

@article{Xu2006ASQ,
  title={A self-assembled quantum dot probe for detecting beta-lactamase activity.},
  author={Chenjie Xu and Bengang Xing and Jianghong Rao},
  journal={Biochemical and biophysical research communications},
  year={2006},
  volume={344 3},
  pages={
          931-5
        }
}
This communication describes a quantum dot probe that can be activated by a reporter enzyme, beta-lactamase. Our design is based on the principle of fluorescence resonance energy transfer (FRET). A biotinylated beta-lactamase substrate was labeled with a carbocyanine dye, Cy5, and immobilized on the surface of quantum dots through the binding of biotin to streptavidin pre-coated on the quantum dots. In assembling this nanoprobe, we have found that both the distance between substrates and the… CONTINUE READING

Citations

Publications citing this paper.
SHOWING 1-10 OF 20 CITATIONS

Bio-functionalised nanoparticles for enzyme sensing

VIEW 5 EXCERPTS
CITES BACKGROUND
HIGHLY INFLUENCED

Nanomedicine in coronary artery disease

VIEW 1 EXCERPT
CITES BACKGROUND

Probing dynamic fluorescence properties of single and clustered quantum dots toward quantitative biomedical imaging of cells.

References

Publications referenced by this paper.
SHOWING 1-10 OF 26 REFERENCES

In vivo imaging of tumors with protease - activated near - infrared fluorescent probes

  • C. H. Tung Weissleder, U. Mahmood, A. Bogdanov
  • J . Am . Chem . Soc .
  • 2005

Protease-activated quantum dot probes.

VIEW 1 EXCERPT