A selective small molecule c-MET Inhibitor, PHA665752, cooperates with rapamycin.

@article{Ma2005ASS,
  title={A selective small molecule c-MET Inhibitor, PHA665752, cooperates with rapamycin.},
  author={Patrick C. H. Ma and Erik Schaefer and James G. Christensen and Ravi Salgia},
  journal={Clinical cancer research : an official journal of the American Association for Cancer Research},
  year={2005},
  volume={11 6},
  pages={2312-9}
}
PURPOSE c-MET is believed to be an attractive receptor target for molecular therapeutic inhibition. TPR-MET, a constitutively active oncogenic variant of MET, serves as excellent model for testing c-MET inhibitors. Here, we characterized a small molecule c-MET inhibitor, PHA665752, and tested its cooperation with the mammalian target of rapamycin inhibitor as potential targeted therapy. EXPERIMENTAL DESIGN The effect of PHA665752 treatment was determined on cell growth, motility and migration… CONTINUE READING
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