A selective review of medical cannabis in cancer pain management.

  title={A selective review of medical cannabis in cancer pain management.},
  author={Alexia Blake and Bo Angela Wan and Leila Malek and Carlo DeAngelis and Patrick L. Diaz and Nicholas Lao and Edward Chow and Shannon O’Hearn},
  journal={Annals of palliative medicine},
  volume={6 Suppl 2},
Insufficient management of cancer-associated chronic and neuropathic pain adversely affects patient quality of life. Patients who do not respond well to opioid analgesics, or have severe side effects from the use of traditional analgesics are in need of alternative therapeutic op-tions. Anecdotal evidence suggests that medical cannabis has potential to effectively manage pain in this patient population. This review presents a selection of representative clinical studies, from small pilot… 

Tables from this paper

Practical Considerations for the Use of Cannabis in Cancer Pain Management—What a Medical Oncologist Should Know

Various preclinical and observational studies have aimed to prove that cannabinoids could be effective in cancer pain management, however, their clinical utility must be further supported by high-quality clinical trials.

An Update of Current Cannabis-Based Pharmaceuticals in Pain Medicine

Clinicians are provided with an update of currently available and promising developmental cannabis pharmaceutical derivatives which may stand to greatly benefit patients with otherwise difficult-to-treat chronic conditions.

Natural products as a perspective for cancer pain management: A systematic review.

Clinical Research Evidence Supporting Administration and Dosing Recommendations of Medicinal Cannabis as Analgesic in Cancer Patients

Clinical research supporting administration of medicinal cannabis in cancer patients for analgesic purposes is elucidated, and high-quality RCTs are scarce in this research field, and the limitations of the observational studies complicates interpretation of clinical outcomes.

Perspectives in veterinary medicine on the use of cannabinoids as complementary palliative therapy for pain in cancer patients

The present study aimed to review articles on the use of cannabinoids in the control of pain contributing to the well-being and quality of life in cancer patients undergoing palliative care to believe that such patients can benefit from this therapeutic modality.

Opportunities for cannabis in supportive care in cancer

There is a reasonable amount of evidence to consider cannabis for nausea and vomiting, loss of appetite, and pain as a supplement to first-line treatments, and promising evidence to treat chemotherapy-induced peripheral neuropathy, gastrointestinal distress, and sleep disorders, but the literature is thus far too limited to recommend cannabis for these symptoms.

Cannabinoids as an Alternative Option for Conventional Analgesics in Cancer Pain Management: A Pharmacogenomics Perspective

This review organizes the current knowledge in the context of SNPs associated with opioids and nonopioids and its clinical consequences in pain management and pharmacogenetic targets of cannabinoids, for use in clinical practice.

A Comprehensive Review of Cannabis in Patients with Cancer: Availability in the USA, General Efficacy, and Safety

Though prospective clinical trials are needed to provide the robust data required to establish the proper role of cannabinoid and cannabis-based therapy in cancer patients, physicians can draw upon the knowledge currently available to have informed discussions with their patients.

Pharmacologic Management of Persistent Pain in Cancer Survivors

The pharmacologic management of entities such as post-surgical pain, chemotherapy-induced neuropathy, aromatase inhibitor musculoskeletal syndrome and checkpoint inhibitor-related pain are described and the challenges associated with opioid prescribing in this population are given special attention.



Cannabinoids for Medical Use: A Systematic Review and Meta-analysis.

There was moderate- quality evidence to support the use of cannabinoids for the treatment of chronic pain and spasticity and low-quality evidence suggesting that cannabinoids were associated with improvements in nausea and vomiting due to chemotherapy, weight gain in HIV infection, sleep disorders, and Tourette syndrome.

Pain and Poppies: The Good, the Bad, and the Ugly of Opioid Analgesics

This review highlights recent breakthroughs in understanding the key causes of these adverse effects and explores the cellular control of opioid systems in reward and aversion, which will challenge traditional views of the good, the bad, and the ugly of opioids.

Nabiximols for opioid-treated cancer patients with poorly-controlled chronic pain: a randomized, placebo-controlled, graded-dose trial.

The impact of pain management on quality of life.

The therapeutic potential of cannabis and cannabinoids.

There is now clear evidence that cannabinoids are useful for the treatment of various medical conditions.

Cancer Pain: A Critical Review of Mechanism-based Classification and Physical Therapy Management in Palliative Care

  • S. Kumar
  • Medicine, Psychology
    Indian journal of palliative care
  • 2011
Effective palliative physical therapy care using a mechanism-based classification model should be tailored to suit each patient's findings, using a biopsychosocial model of pain.

Codeine, alone and with paracetamol (acetaminophen), for cancer pain.

The efficacy and safety of codeine used alone or in combination with paracetamol for relieving cancer pain was determined, and codeine or codeine plus par acetamol was numerically superior to placebo and equivalent to the active comparators.

Pain management of the cancer patient.

  • R. Ignoffo
  • Medicine
    Frontiers of radiation therapy and oncology
  • 1980
In summary, there are several ways to manage chronic pain with pharmacologic agents. The clinician should consider adjunctive agents such as antidepressants, stimulants, and antianxiety drugs as well

Current aproach to cancer pain management: Availability and implications of different treatment options

This review article attempted to provide the comprehensive information about different options available nowadays for treating cancer pain focusing on most widely used pharmacologic agents, surgical modalities for intractable pain control, their potential for adverse effects, and ways to increase the effectiveness of treatment maximally optimizing analgesic regimen and improving compliance.