A selective irreversible inhibitor targeting a PDZ protein interaction domain.

  title={A selective irreversible inhibitor targeting a PDZ protein interaction domain.},
  author={Naoaki Fujii and Jose J. Haresco and Kathleen A P Novak and David Stokoe and Irwin D. Kuntz and R. Kiplin Guy},
  journal={Journal of the American Chemical Society},
  volume={125 40},
Irreversible inhibitors of proteases have proven themselves useful tools for determining which proteases are active under given conditions in tissues or cells and for studying the functional role that a protease plays in physiological processes. The application of such techniques to the study of the activity and function of protein-protein interactions has been hindered by the lack of guiding principles for the mechanistic design of irreversible inhibitors targeting the "active site" of a… CONTINUE READING


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