A selective inhibitor of serotonin uptake: Lilly 110140, 3-(p-trifluoromethylphenoxy)-N-methyl-3-phenylpropylamine.

  title={A selective inhibitor of serotonin uptake: Lilly 110140, 3-(p-trifluoromethylphenoxy)-N-methyl-3-phenylpropylamine.},
  author={David T. Wong and J. S. Horng and Frank P. Bymaster and Kenneth Lee Hauser and Bryan B. Molloy},
  journal={Life sciences},
  volume={15 3},

Pharmacologic effects in man of a specific serotonin-reuptake inhibitor.

Fluoxetine (Li-ly 110140) caused a 63 percent inhibition of [3H]serotonin uptake into platelets obtained from normal volunteers to whom the drug was administered daily for 7 days. This dose had no

Inhibition of serotonin uptake by optical isomers of fluoxetine

The optical isomers of fluoxetine, a selective inhibitor of serotonin (5‐hydroxytryptamine, 5HT) uptake, have been compared pharmacologically and the (−)‐isomer had a much shorter duration of action than the (+)‐ isomer in rats.

Synthesis of [18F]‐(S)‐fluoxetine: A selective serotonine uptake inhibitor

The (S)-N-methyl-γ-[4-(trifluoromethyl)phenoxy]benzenepropanamine, an antidepressant with potential applications in the treatment of other illnesses was labelled with fluorine-18 for Positron

SL 81.0385: A novel selective and potent serotonin uptake inhibitor

The present results indicate that SL 81.0385 is a highly potent and selective inhibitor of serotonin uptake, chemically unrelated to the tricyclics, and it should find application in the treatment of depression, obesity, and alcoholism.



The effect of imipramine of central 5‐hydroxytryptamine neurons

It is observed that imipramine is capable of blocking this mechanism in the 5-HT neurons, which has recently been obtained that there exist also in the central 5-hydroxytryptamine neurons a reserpine-resistant uptake-concentration mechanism for amines.

Effect of drugs on the uptake and metabolism of H3-norepinephrine.

The catechol-O-methyl transferase inhibitor, pyrogallol, elevated the concentration of H 3 - norepinephrine in heart, spleen, liver and muscle but not the adrenal gland and plasma, and lowered the concentration in these tissues except the heart and spleen.

Biochemical and histochemical studies on the effects of imipramine-like drugs and (+)-amphetamine on central and peripheral catecholamine neurons.

It is concluded that desipramine and protriptyline are able to block the reserpine-resistant amine- concentrating mechanism of central and peripheral NA, but not DA fibres, whereas (+)-amphet- amine appears to cause release of amines from extragranular locations within both NA andDA fibres.

Regional differences in H3-norepinephrine and H3-dopamine uptake into rat brain homogenates.

  • S. SnyderJ. Coyle
  • Biology, Chemistry
    The Journal of pharmacology and experimental therapeutics
  • 1969
The uptake of DL-H 3 -norepinephrine and H 3 -dopamine has been examined in rat brain homogenates and it is shown that this high-affinity uptake for dopamine appears to utilize the norepinepinephrine transport system.

Indoleamine metabolites in the cerebrospinal fluid of depressed patients before and during treatment with nortriptyline

The data suggest that endogenous depression is a hiochemically heterogenous disease and there may be a subgroup of patients within the endogenous syndrome where indoleamine metabolism is disturbed, and treatment with drugs that influence indoleamines more directly than a typical noradrenaline uptake inhibitor like nortriptyline, may lead to better therapeutic results.

The determination of enzyme inhibitor constants.

  • M. Dixon
  • Biology, Computer Science
    The Biochemical journal
  • 1953
Briggs, G. E. & Haldane, J. B. S. (1925). Biochem. J. 19,338. Chance, B. (1952). J. biol. Chem. 194, 483. Delory, G. E. & King, E. J. (1943). Biochem. J. 37, 547. Dixon, M. (1949). Multi-enzyme