A selective fluorescent sensor for detecting lead in living cells.

@article{He2006ASF,
  title={A selective fluorescent sensor for detecting lead in living cells.},
  author={Qiwen He and Evan W Miller and Audrey P Wong and Christopher J Chang},
  journal={Journal of the American Chemical Society},
  year={2006},
  volume={128 29},
  pages={9316-7}
}
We present the synthesis, properties, and biological applications of Leadfluor-1 (LF1), a new water-soluble, turn-on fluorescent sensor that is capable of selectively imaging Pb2+ in aqueous solution and in living cells. LF1 combines a fluorescein chromophore and a pseudocrown receptor to provide good selectivity for Pb2+ over a range of biologically and environmentally relevant metal ions in aqueous solution, with sensitivity to parts per billion EPA limits for allowable lead in drinking water… CONTINUE READING

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