A selective defect in IgG2b switching as a result of targeted mutation of the I gamma 2b promoter and exon.

@article{Zhang1993ASD,
  title={A selective defect in IgG2b switching as a result of targeted mutation of the I gamma 2b promoter and exon.},
  author={Jian qing Zhang and Andrea Bottaro and Suiyang Li and V. Stewart and Frederick W Alt},
  journal={The EMBO journal},
  year={1993},
  volume={12 9},
  pages={
          3529-37
        }
}
LPS stimulation of B lymphocytes induces germline transcription of and subsequent switching to the gamma 2b gene. Mature germline transcripts contain an I exon (non-coding) spliced to the C gamma 2b exons. To investigate the role of germline transcription and/or transcripts in heavy chain class switching, we have replaced the germline I gamma 2b promoter and I exon in ES cells with an expressed neomycin resistance gene. The mutated chromosome retains the downstream target sequence for switch… CONTINUE READING
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