A selective cyclooxygenase-2 inhibitor decreases proteinuria and retards progressive renal injury in rats.

@article{Wang2000ASC,
  title={A selective cyclooxygenase-2 inhibitor decreases proteinuria and retards progressive renal injury in rats.},
  author={J L Wang and H F Cheng and Scott Shappell and Raymond C Harris},
  journal={Kidney international},
  year={2000},
  volume={57 6},
  pages={2334-42}
}
BACKGROUND We have previously shown that cyclooxygenase-2 (COX-2) expression is low in the renal cortex of adult rats, but is increased in macula densa/cortical thick ascending limb and in glomerular podocytes after subtotal renal ablation. METHODS To evaluate the functional consequences of this increased COX-2 expression, male rats were subjected to subtotal renal ablation and divided into four groups: (1) treatment with the selective COX-2 inhibitor SC58236, (2) treatment with vehicle, (3… CONTINUE READING

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