A selective androgen receptor modulator with minimal prostate hypertrophic activity enhances lean body mass in male rats and stimulates sexual behavior in female rats

@article{Allan2007ASA,
  title={A selective androgen receptor modulator with minimal prostate hypertrophic activity enhances lean body mass in male rats and stimulates sexual behavior in female rats},
  author={G. Allan and P. Tannenbaum and Tifanie Sbriscia and Olivia Linton and Muh-Tsann Lai and D. Haynes-Johnson and S. Bhattacharjee and Xuqing Zhang and Z. Sui and S. Lundeen},
  journal={Endocrine},
  year={2007},
  volume={32},
  pages={41-51}
}
Androgen receptor (AR) ligands with tissue selectivity (selective androgen receptor modulators, or SARMs) have potential for treating muscle wasting, hypogonadism of aging, osteoporosis, female sexual dysfunction, and other indications. JNJ-28330835 is a nonsteroidal AR ligand with mixed agonist and antagonist activity in androgen-responsive cell-based assays. It is an orally active SARM with muscle selectivity in orchidectomized rat models. It stimulated growth of the levator ani muscle… Expand
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