A selective Nav1.8 sodium channel blocker, A-803467 [5-(4-chlorophenyl-N-(3,5-dimethoxyphenyl)furan-2-carboxamide], attenuates spinal neuronal activity in neuropathic rats.

@article{McGaraughty2008ASN,
  title={A selective Nav1.8 sodium channel blocker, A-803467 [5-(4-chlorophenyl-N-(3,5-dimethoxyphenyl)furan-2-carboxamide], attenuates spinal neuronal activity in neuropathic rats.},
  author={Steve P McGaraughty and Katharine L. Chu and Marc J C Scanio and Michael Kort and Connie R. Faltynek and Michael F. Jarvis},
  journal={The Journal of pharmacology and experimental therapeutics},
  year={2008},
  volume={324 3},
  pages={1204-11}
}
We have recently reported that systemic delivery of A-803467 [5-(4-chlorophenyl-N-(3,5-dimethoxyphenyl)furan-2-carboxamide], a selective Na(v)1.8 sodium channel blocker, reduces behavioral measures of chronic pain. In the current study, the effects of A-803467 on evoked and spontaneous firing of wide dynamic range (WDR) neurons were measured in uninjured and rats with spinal nerve ligations (SNLs). Administration of A-803467 (10-30 mg/kg i.v.) reduced mechanically evoked (10-g von Frey hair… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 26 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 47 references

Nav 1.8-null mice

EA 877–17. Matthews, JN Wood, AH Dickenson
2006
View 6 Excerpts
Highly Influenced

Redistribution of Na(V)1.8 in uninjured axons enables neuropathic pain.

The Journal of neuroscience : the official journal of the Society for Neuroscience • 2003
View 4 Excerpts
Highly Influenced

chronic, neuropathic and inflammatory pain. Neuropharmacology

MS Gold, D Weinreich, +4 authors J Lai
2003
View 6 Excerpts
Highly Influenced

Systemic lidocaine for neuropathic pain relief

View 4 Excerpts
Highly Influenced

Similar Papers

Loading similar papers…