A selective N-methyl-D-aspartate antagonist depresses epileptiform activity in rat hippocampal slices.

@article{Herron1985ASN,
  title={A selective N-methyl-D-aspartate antagonist depresses epileptiform activity in rat hippocampal slices.},
  author={Caroline E. Herron and Roddy Williamson and Graham L Collingridge},
  journal={Neuroscience letters},
  year={1985},
  volume={61 3},
  pages={255-60}
}
The sensitivity of convulsant-induced epileptiform activity in the hippocampus to the selective N-methyl-D-aspartate (NMDA) antagonist D-2-amino-5-phosphonovalerate (D-APV) was examined using in vitro electrophysiological techniques. This compound reduced the number and size of the synaptically evoked population spikes recorded in the CA1 region in the presence of the convulsants, pentylenetetrazol, bicuculline or folate. Intracellular recordings in the presence of bicuculline showed that D-APV… CONTINUE READING

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