A selective CCKB receptor antagonist potentiates, mu-, but not delta-opioid receptor-mediated antinociception in the formalin test.

Abstract

The endogenous peptides enkephalins and cholecystokinin appear to play an opposite role in the control of pain. In this work, the effect of the selective CCKB receptor antagonist PD-134,308 on antinociceptive effects induced by morphine or by a complete inhibitor of enkephalin-metabolizing enzymes, RB 101, was studied using the formalin test. In mice, s.c… (More)

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@article{Noble1995ASC, title={A selective CCKB receptor antagonist potentiates, mu-, but not delta-opioid receptor-mediated antinociception in the formalin test.}, author={Florence Noble and Armand G S Blommaert and M-C Fourni{\'e}-Zaluski and B. Roques}, journal={European journal of pharmacology}, year={1995}, volume={273 1-2}, pages={145-51} }