A selected reaction monitoring (SRM)-based method for absolute quantification of Aβ38, Aβ40, and Aβ42 in cerebrospinal fluid of Alzheimer's disease patients and healthy controls.

@article{Pannee2013ASR,
  title={A selected reaction monitoring (SRM)-based method for absolute quantification of Aβ38, Aβ40, and Aβ42 in cerebrospinal fluid of Alzheimer's disease patients and healthy controls.},
  author={Josef Pannee and E. Portelius and M. Oppermann and Alan R. Atkins and M. Hornshaw and I. Zegers and Peter H{\"o}jrup and L. Minthon and O. Hansson and H. Zetterberg and K. Blennow and J. Gobom},
  journal={Journal of Alzheimer's disease : JAD},
  year={2013},
  volume={33 4},
  pages={
          1021-32
        }
}
Cerebrospinal fluid (CSF) biomarkers for Alzheimer's disease (AD) are increasingly used in research centers, clinical trials, and clinical settings. However, their broad-scale use is hampered by lack of standardization across analytical platforms and by interference from binding of amyloid-β (Aβ) to matrix proteins as well as self-aggregation. Here, we report on a matrix effect-resistant method for the measurement of the AD-associated 42 amino acid species of Aβ (Aβ42), together with Aβ40 and A… Expand
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