A seizure-prone phenotype is associated with altered free-running rhythm in Pten mutant mice.

@article{Ogawa2007ASP,
  title={A seizure-prone phenotype is associated with altered free-running rhythm in Pten mutant mice.},
  author={Shiori Ogawa and C K Kwon and Jing Zhou and Della Koovakkattu and Luis F. Parada and Christopher M. Sinton},
  journal={Brain research},
  year={2007},
  volume={1168},
  pages={112-23}
}
Conditional deletion of Pten (phosphatase and tensin homolog on chromosome ten) in differentiated cortical and hippocampal neurons in the mouse results in seizures, macrocephaly, social interaction deficits and anxiety, reminiscent of human autism spectrum disorder. Here we extended our previous examination of these mice using electroencephalogram/electromyogram (EEG/EMG) monitoring and found age-related increases in spontaneous seizures, which were correlated with cellular dispersion in the… CONTINUE READING
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