A segmented principal component analysis--regression approach to QSAR study of peptides.

@article{Hemmateenejad2012ASP,
  title={A segmented principal component analysis--regression approach to QSAR study of peptides.},
  author={Bahram Hemmateenejad and Ramin Miri and Maryam Elyasi},
  journal={Journal of theoretical biology},
  year={2012},
  volume={305},
  pages={37-44}
}
We employed segmented principal component analysis and regression, as a new methodology in quantitative structure-activity relationship (QSAR), to define new amino acid indices. The descriptors are first classified into different groups (based on the similarity in the information contents they are possessing) and then each group is subjected to principal component analysis (PCA), separately. The extracted principal components (PC) from the descriptor data matrix of each group can be considered… CONTINUE READING