A segmental pattern of alkaline phosphatase activity within the notochord coincides with the initial formation of the vertebral bodies.

@article{Grotmol2005ASP,
  title={A segmental pattern of alkaline phosphatase activity within the notochord coincides with the initial formation of the vertebral bodies.},
  author={Sindre Grotmol and Kari Nordvik and Harald Kryvi and Geir K{\aa}re Totland},
  journal={Journal of anatomy},
  year={2005},
  volume={206 5},
  pages={427-36}
}
This study shows that segmental expression of alkaline phosphatase (ALP) activity by the notochord of the Atlantic salmon (Salmo salar L.) coincides with the initial mineralization of the vertebral body (chordacentrum), and precedes ALP expression by presumed somite-derived cells external to the notochordal sheath. The early expression of ALP indicates that the notochord plays an instructive role in the segmental patterning of the vertebral column. The chordacentra form segmentally as… CONTINUE READING

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