A secreted serine-threonine kinase determines virulence in the eukaryotic pathogen Toxoplasma gondii.

Abstract

Toxoplasma gondii strains differ dramatically in virulence despite being genetically very similar. Genetic mapping revealed two closely adjacent quantitative trait loci on parasite chromosome VIIa that control the extreme virulence of the type I lineage. Positional cloning identified the candidate virulence gene ROP18, a highly polymorphic serine-threonine… (More)

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@article{Taylor2006ASS, title={A secreted serine-threonine kinase determines virulence in the eukaryotic pathogen Toxoplasma gondii.}, author={S. Taylor and Antonio Barragan and C. Su and Blima Fux and Sarah J. Fentress and K. Tang and Wandy L. Beatty and Hazem Hajj and Maria E Jerome and Michael S Behnke and M. White and J. C. Wootton and L. David Sibley}, journal={Science}, year={2006}, volume={314 5806}, pages={1776-80} }