A secreted luciferase for ex vivo monitoring of in vivo processes

@article{Wurdinger2008ASL,
  title={A secreted luciferase for ex vivo monitoring of in vivo processes},
  author={Thomas D. Wurdinger and Christian E. Badr and Lisa S Pike and Ruben de Kleine and Ralph Weissleder and Xandra O Breakefield and Bakhos A. Tannous},
  journal={Nature Methods},
  year={2008},
  volume={5},
  pages={171-173}
}
Luciferases are widely used to monitor biological processes. Here we describe the naturally secreted Gaussia princeps luciferase (Gluc) as a highly sensitive reporter for quantitative assessment of cells in vivo by measuring its concentration in blood. The Gluc blood assay complements in vivo bioluminescence imaging, which has the ability to localize the… CONTINUE READING
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