A second two-component regulatory system of Bordetella bronchiseptica required for bacterial resistance to oxidative stress, production of acid phosphatase, and in vivo persistence.

@article{Jungnitz1998AST,
  title={A second two-component regulatory system of Bordetella bronchiseptica required for bacterial resistance to oxidative stress, production of acid phosphatase, and in vivo persistence.},
  author={Heidrun Jungnitz and Nicholas P West and Mark J Walker and Gursharan Singh Chhatwal and Carlos Alberto Guzm{\'a}n},
  journal={Infection and immunity},
  year={1998},
  volume={66 10},
  pages={4640-50}
}
Random minitransposon mutagenesis was used to identify genes involved in the survival of Bordetella bronchiseptica within eukaryotic cells. One of the mutants which exhibited a reduced ability to survive intracellularly harbored a minitransposon insertion in a locus (ris) which displays a high degree of homology to two-component regulatory systems. This system exhibited less than 25% amino acid sequence homology to the only other two-component regulatory system described in Bordetella spp., the… CONTINUE READING