A second subunit of CD8 is expressed in human T cells.

  title={A second subunit of CD8 is expressed in human T cells.},
  author={Anne M. Norment and Dan R. Littman},
  journal={The EMBO journal},
  volume={7 11},
The CD8 glycoprotein plays important functions in T cell development and in T cell activation. In rodents, CD8 is a heterodimer, consisting of an alpha-chain (Lyt2) and a beta-chain (Lyt3). In humans, only the alpha-chain has been detected, and it has been thought that CD8 consists of homodimers of this protein. We have isolated functional cDNA clones encoding human CD8 beta, and show that the CD8 beta protein is expressed on the surface of CD8+ human T cells. cDNA clones encoding multiple… CONTINUE READING


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