A second prophylactic MHC-mismatched bone marrow transplantation protects against rat acute myeloid leukemia (BNML) without lethal graft-versus-host disease.

@article{Nestvold2008ASP,
  title={A second prophylactic MHC-mismatched bone marrow transplantation protects against rat acute myeloid leukemia (BNML) without lethal graft-versus-host disease.},
  author={Janne M. Nestvold and Bente K Omdal and Ke-Zheng Dai and Anton C. M. Martens and Haakon Breien Benestad and John Torgils Vaage and Bent Rolstad},
  journal={Transplantation},
  year={2008},
  volume={85 1},
  pages={102-11}
}
BACKGROUND We have employed a rat model for human acute myeloid leukemia, a promyelocytic leukemia in the BN rat strain (BNML), to develop new protocols for immunotherapy in combination with allogeneic bone marrow transplantation (alloBMT). The status of mixed chimerism in allotransplanted rats provided an opportunity for immunotherapy using alloreactive donor cells. In addition to T or natural killer (NK) cells, we introduced a second infusion of bone marrow cells as prophylactic donor… CONTINUE READING
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