A second paroxysmal kinesigenic choreoathetosis locus (EKD2) mapping on 16q13-q22.1 indicates a family of genes which give rise to paroxysmal disorders on human chromosome 16.

@article{Valente2000ASP,
  title={A second paroxysmal kinesigenic choreoathetosis locus (EKD2) mapping on 16q13-q22.1 indicates a family of genes which give rise to paroxysmal disorders on human chromosome 16.},
  author={Enza Maria Valente and Si{\^a}n D Spacey and Gurusidheshwar M. Wali and Kailish P Bhatia and Peter H. Dixon and Nicholas Wood and M. Benjamin Davis},
  journal={Brain : a journal of neurology},
  year={2000},
  volume={123 ( Pt 10)},
  pages={2040-5}
}
Paroxysmal kinesigenic choreoathetosis (PKC) is a rare paroxysmal movement disorder characterized by recurrent and brief attacks of choreiform or dystonic movements triggered or exacerbated by sudden voluntary movements. Some patients with PKC also have a history of infantile afebrile convulsions. PKC can be sporadic, or familial with autosomal dominant inheritance. PKC has been mapped to the pericentromeric region of human chromosome 16 in several Japanese families and in an African-American… CONTINUE READING