A second p53-related protein, p73L, with high homology to p73.

  title={A second p53-related protein, p73L, with high homology to p73.},
  author={Makoto Senoo and Naohiko Seki and Miki Ohira and Sumio Sugano and Masatomo Watanabe and Sawako Inuzuka and Takashi Okamoto and Maki Tachibana and Takahiro Tanaka and Yasuhiro Shinkai and Hitoshi Kato},
  journal={Biochemical and biophysical research communications},
  volume={248 3},
The p53 protein, which regulates the rate of cell division and death, is the most frequently mutated tumor suppressor to be identified so far in human cancers. Recently, a gene with significant homology to p53, termed p73, has been identified in a chromosomal region that is implicated in the molecular pathogenesis of neuroblastoma. We have cloned a second human p53-related gene, termed p73L, which shows strong amino-acid similarity to p73. The p73L gene is mapped to human chromosome 3q27-28… CONTINUE READING


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