A second-order simulation model of the cost-effectiveness of managing dyspepsia in the United States.

@article{Barton2008ASS,
  title={A second-order simulation model of the cost-effectiveness of managing dyspepsia in the United States.},
  author={Pelham M. Barton and Paul M Moayyedi and Nicholas J Talley and Nimish Vakil and Brendan C Delaney},
  journal={Medical decision making : an international journal of the Society for Medical Decision Making},
  year={2008},
  volume={28 1},
  pages={44-55}
}
BACKGROUND The "gold-standard'' evidence of effectiveness for a clinical practice guideline is the randomized controlled trial (RCT), although RCTs have a limited ability to explore potential management strategies for a chronic disease where these interact over time. Modeling can be used to fill this gap, and models have become increasingly complex, with both dynamic sampling and representation of second-order uncertainty to provide more precise estimates. However, both simulation modeling and… CONTINUE READING

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