A second major histocompatibility complex susceptibility locus for multiple sclerosis

@inproceedings{Yeo2007ASM,
  title={A second major histocompatibility complex susceptibility locus for multiple sclerosis},
  author={Tai Wai Yeo and Philip L De Jager and Simon G. Gregory and Lisa F. Barcellos and Amie Walton and An Goris and Chiara Fenoglio and Maria Ban and Craig J. Taylor and Reyna S. Goodman and Emily Walsh and Cara S. Wolfish and Roger Horton and James Traherne and Stephan Beck and John Trowsdale and Stacy J. Caillier and Adrian Ivinson and Todd Green and Susan Pobywajlo and Eric S. Lander and Margaret A. Pericak-Vance and Jonathan L. Haines and Mark J. Daly and Jorge Oksenberg and Stephen L. Hauser and Alastair D Compston and David A. Hafler and John D Rioux and Stephen J Sawcer},
  booktitle={Annals of neurology},
  year={2007}
}
OBJECTIVE Variation in the major histocompatibility complex (MHC) on chromosome 6p21 is known to influence susceptibility to multiple sclerosis with the strongest effect originating from the HLA-DRB1 gene in the class II region. The possibility that other genes in the MHC independently influence susceptibility to multiple sclerosis has been suggested but remains unconfirmed. METHODS Using a combination of microsatellite, single nucleotide polymorphism, and human leukocyte antigen (HLA) typing… CONTINUE READING
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