A second-generation phosphohistidine analog for production of phosphohistidine antibodies.

@article{Kee2015ASP,
  title={A second-generation phosphohistidine analog for production of phosphohistidine antibodies.},
  author={Jung-Min Kee and Rob C. Oslund and Anthony D. Couvillon and Tom W Muir},
  journal={Organic letters},
  year={2015},
  volume={17 2},
  pages={187-9}
}
Protein histidine phosphorylation plays a crucial role in cell signaling and central metabolism. However, its detailed functions remain elusive due to technical challenges in detecting and isolating proteins bearing phosphohistidine (pHis), a labile posttranslational modification (PTM). To address this issue, we previously developed the first pHis-specific… CONTINUE READING