A second-generation association study of the 5q31 cytokine gene cluster and the interleukin-4 receptor in asthma.

@article{Kauppi2001ASA,
  title={A second-generation association study of the 5q31 cytokine gene cluster and the interleukin-4 receptor in asthma.},
  author={Paula Kauppi and Kerstin Lindblad-Toh and Petteri Sevon and Heikki Toivonen and John D Rioux and Anuradha C Villapakkam and Lauri A. Laitinen and Thomas J. Hudson and Juha Kere and Tarja Laitinen},
  journal={Genomics},
  year={2001},
  volume={77 1-2},
  pages={35-42}
}
We have analyzed a dense set of single-nucleotide polymorphisms (SNPs) and microsatellites spanning the T-helper cytokine gene cluster (interleukins 3, 4, 5, 9, and 13, interferon regulatory factor-1, colony-stimulating factor-2, and T-cell transcription factor-7) on 5q31 and the gene encoding the interleukin-4 receptor (IL4R) on 16p12 among Finnish families with asthma. As shown by haplotype pattern mining analysis, the number of disease-associated haplotype patterns differed from that… CONTINUE READING
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