A second-generation 99m technetium single photon emission computed tomography agent that provides in vivo images of the dopamine transporter in primate brain.

@article{Meltzer2003AS9,
  title={A second-generation 99m technetium single photon emission computed tomography agent that provides in vivo images of the dopamine transporter in primate brain.},
  author={Peter C. Meltzer and Paul Blundell and Thomas Zona and Lihua Yang and Hong Huang and Ali Akbarpour Bonab and Eli Livni and Alan J. Fischman and Bertha K. Madras},
  journal={Journal of medicinal chemistry},
  year={2003},
  volume={46 16},
  pages={3483-96}
}
The dopamine transporter (DAT), located presynaptically on dopamine neurons, provides a marker for Parkinson's disease (Pd) and attention deficit hyperactivity disorder (ADHD). In ADHD, DAT density levels are elevated, while in Pd these levels are depleted. The depletion of DAT levels also corresponds with the loss of dopamine. We now describe the design… CONTINUE READING