A second cytotoxic proteolytic peptide derived from amyloid β-protein precursor

  title={A second cytotoxic proteolytic peptide derived from amyloid β-protein precursor},
  author={Daniel C. Lu and Shahrooz Rabizadeh and Sreeganga Chandra and Rana F. Shayya and Lisa M. Ellerby and Xin Ye and Guy Salvesen and Edward H. Koo and Dale E. Bredesen},
  journal={Nature Medicine},
The amyloid β-protein precursor gives rise to the amyloid β-protein, the principal constituent of senile plaques and a cytotoxic fragment involved in the pathogenesis of Alzheimer disease. Here we show that amyloid β-protein precursor was proteolytically cleaved by caspases in the C terminus to generate a second unrelated peptide, called C31. The resultant C31 peptide was a potent inducer of apoptosis. Both caspase-cleaved amyloid β-protein precursor and activated caspase-9 were present in… CONTINUE READING

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