A second class of chemosensory receptors in the olfactory epithelium

@article{Liberles2006ASC,
  title={A second class of chemosensory receptors in the olfactory epithelium},
  author={Stephen D Liberles and Linda B Buck},
  journal={Nature},
  year={2006},
  volume={442},
  pages={645-650}
}
The mammalian olfactory system detects chemicals sensed as odours as well as social cues that stimulate innate responses. Odorants are detected in the nasal olfactory epithelium by the odorant receptor family, whose ∼1,000 members allow the discrimination of a myriad of odorants. Here we report the discovery of a second family of receptors in the mouse olfactory epithelium. Genes encoding these receptors, called ‘trace amine-associated receptors’ (TAARs), are present in human, mouse and fish… Expand
Trace Amine‐associated Receptors Are Olfactory Receptors in Vertebrates
  • S. Liberles
  • Biology, Medicine
  • Annals of the New York Academy of Sciences
  • 2009
TLDR
Mouse TAARs are reported to be enriched in the urine of stressed animals, and two others, trimethylamine and isoamylamine, are enriched in male versus female urine, raising the possibility that some TAars are pheromone receptors in the nose, a hypothesis consistent with recent data suggesting that the olfactory epithelium contains dedicated pherOMone receptors, separate from phersomone receptor in the vomeronasal organ. Expand
Mammalian Olfactory Receptors
TLDR
Olfactory receptors play a key role for a reliable recognition and an accurate processing of chemosensory information and are considered as key elements for an understanding of the principles and mechanisms underlying the sense of smell. Expand
Role of a Ubiquitously Expressed Receptor in the Vertebrate Olfactory System
TLDR
Loss-of-function experiments in zebrafish embryos demonstrate that OlfCc1 is required for olfactory responses to a diverse mixture of polar, nonpolar, acidic, and basic amino acids, and suggest that it plays a role in the function and/or intracellular trafficking of other Olfactory and vomeronasal receptors with which it is coexpressed. Expand
Deorphanization of Olfactory Trace Amine-Associated Receptors.
  • Qian Li
  • Biology, Medicine
  • Methods in molecular biology
  • 2018
TLDR
This chapter focuses on the so-called SEAP assay that has been successfully applied for TAAR deorphanization in different species and identification of additional high-affinity ligands for TAARS will provide extra tools for such study. Expand
Searching for the Ligands of Odorant Receptors
  • B. Malnic
  • Biology, Medicine
  • Molecular Neurobiology
  • 2007
TLDR
These studies are complicated by the extremely large size of the odorant receptor family and by the poor functional expression of these receptors in heterologous cells. Expand
Diverse Systems for Pheromone Perception: Multiple Receptor Families in Two Olfactory Systems
TLDR
The systems for pheromone perception in vertebrates are far more complex than previously predicted and appears to differ among various vertebrate species. Expand
Human Olfactory Receptor Families and Their Odorants
TLDR
Different screening strategies will shed light on the yet sparsely available odorant specificity profiles and structure–function relationships of olfactory receptors, as well as the structure–activity relationships of their odorants. Expand
Ultrasensitive Detection of Amines by a Trace Amine-Associated Receptor
TLDR
Surprisingly, it is found that TAAR4 is exquisitely sensitive, with apparent affinities for a preferred ligand, phenylethylamine, rivaling those seen with mammalian pheromone receptors. Expand
A Family of non-GPCR Chemosensors Defines an Alternative Logic for Mammalian Olfaction
TLDR
It is reported that members of the four-pass transmembrane MS4A protein family are chemosensors expressed within necklace sensory neurons, which define a distinct mechanism and functional logic for mammalian olfaction. Expand
Olfactory signaling via trace amine-associated receptors
  • Adam Dewan
  • Medicine, Biology
  • Cell and tissue research
  • 2020
TLDR
The small size of this receptor family combined with the ethological relevance of their ligands makes the TAARs an attractive model system for probing Olfactory perception and whether they represent a unique subsystem within the main olfactory system is discussed. Expand
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