A second calcineurin binding site on the NFAT regulatory domain.

  title={A second calcineurin binding site on the NFAT regulatory domain.},
  author={Stella Y. Park and Motonari Uesugi and Gregory L. Verdine},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={97 13},
NFATc (a member of the family of nuclear factors of activated T cells) is a transcriptional factor responsible for the Ca(2+)-inducible activation of cytokine genes during the immune response. In resting T cells, NFATc is retained in the cytoplasm by a mechanism that depends on multiple phosphorylations in an N-terminal regulatory domain. Physical interaction with and dephosphorylation by Ca(2+)-activated calcineurin (Cn) allows the protein to enter the nucleus, where it binds to specific sites… CONTINUE READING


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