A second autosomal split hand/split foot locus maps to chromosome 10q24-q25.

@article{Nues1995ASA,
  title={A second autosomal split hand/split foot locus maps to chromosome 10q24-q25.},
  author={M. Nu{\~n}es and G. Schutt and R. Kapur and F. Luthardt and M. Kukolich and P. Byers and J. P. Evans},
  journal={Human molecular genetics},
  year={1995},
  volume={4 11},
  pages={
          2165-70
        }
}
Ectrodactyly (split hand/split foot malformation, SHSF) is a human limb malformation characterized by absent central digital rays, deep median cleft, and syndactyly of remaining digits. The disorder is genetically heterogeneous, with at least two loci thus far determined: an autosomal locus at 7q21 designated SHFM1 and an X-linked locus at Xq26 designated SHFM2. Cytogenetic analysis of sporadic SHSF patients and linkage studies in extended pedigrees both suggest more than one autosomal locus… Expand
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