A second autosomal split hand/split foot locus maps to chromosome 10q24-q25.

  title={A second autosomal split hand/split foot locus maps to chromosome 10q24-q25.},
  author={M. Nu{\~n}es and G. Schutt and R. Kapur and F. Luthardt and M. Kukolich and P. Byers and J. P. Evans},
  journal={Human molecular genetics},
  volume={4 11},
Ectrodactyly (split hand/split foot malformation, SHSF) is a human limb malformation characterized by absent central digital rays, deep median cleft, and syndactyly of remaining digits. The disorder is genetically heterogeneous, with at least two loci thus far determined: an autosomal locus at 7q21 designated SHFM1 and an X-linked locus at Xq26 designated SHFM2. Cytogenetic analysis of sporadic SHSF patients and linkage studies in extended pedigrees both suggest more than one autosomal locus… Expand
72 Citations
Fine mapping of the split-hand/split-foot locus (SHFM3) at 10q24: evidence for anticipation and segregation distortion.
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Genomic rearrangement at 10q24 in non-syndromic split-hand/split-foot malformation
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A split hand-split foot (SHFM3) gene is located at 10q24-->25.
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Homozygous sequence variants in the WNT10B gene underlie split hand/foot malformation
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