A search for the genotoxic principle associated with the tubercule bacillus, Mycobacterium tuberculosis using mice as model.

@article{Manna1990ASF,
  title={A search for the genotoxic principle associated with the tubercule bacillus, Mycobacterium tuberculosis using mice as model.},
  author={Gennaro Manna and Sudeshna Pal},
  journal={Cytologia},
  year={1990},
  volume={55},
  pages={381-386}
}
The genotoxic principle associated with the tubercule bacilli, Mycobacterium tuberculosis has been investigated using bone marrow chromosome aberration frequency as the indicator in different sets of experimentally treated mice against controls. The data scored from 400 metaphase plates of 2 male and 2 female mice on 7th day after injection in each series revealed the average aberration frequency of 27.50% in log culture, 11.25% in culture filtrate, 17.50% in isolated bacteria in saline… Expand
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References

SHOWING 1-8 OF 8 REFERENCES
A colchicine, hypotonic citrate, squash sequence for mammalian chromosomes.
The method was developed for bone marrow of mice but is applicable to other tissues and other species of small mammals. Mice are injected intraperitoneally with 0.5 ml of 0.025% colchicine solutionExpand
System for the evaluation of the risk from chemical mutagens for man: basic principles and practical recommendations.
TLDR
From the hygienic aspect it is recommended, as a temporary measure, to evaluate a chemical mutagen and to prohibit or limit its use if its average population dose produces a 0.1% or greater increase in the spontaneous level of mutations. Expand
Medical Microbiology
TLDR
The microbiology of important infectious diseases is studied, including tetanus, diphtheria, pneumonia, typhoid and paratyphoid fever, staphylococcus and streptococcus infections, etc. Expand
An air-drying technique for flattening chromosomes in mammalian oells grown in vitro.
The method described was developed to facilitate the analysis of chromosome complements in cells freshly isolated from monkey kidney cortex and grown on glass, and in “altered” monkey cells grown onExpand
Genotoxic potential of the Inberculin P.P.D. tested in mice
  • CIS (Japan)
  • 1990
Testing of mutagenic potentiality of the tubercular bacterium , Mycobacterium tuber culosis in experimentally treated mice
  • 1989
Chromosome aberrations induced by living mutagens
  • Presidential Address, Sec. B, 43rd Ann. Sess. Nat. Acad. Sci., India, Jodhpur, pp. 1-15.-
  • 1973