A screening for high copy suppressors of the sit4 hal3 synthetically lethal phenotype reveals a role for the yeast Nha1 antiporter in cell cycle regulation.

@article{Simn2001ASF,
  title={A screening for high copy suppressors of the sit4 hal3 synthetically lethal phenotype reveals a role for the yeast Nha1 antiporter in cell cycle regulation.},
  author={Ernesto Sim{\'o}n and J. Clotet and Fernando Calero and Jose Ramos and Joaqu{\'i}n Ari{\~n}o},
  journal={The Journal of biological chemistry},
  year={2001},
  volume={276 32},
  pages={29740-7}
}
A screening for multicopy suppressors of the G(1)/S blockage of a conditional sit4 hal3 mutant yielded the NHA1 gene, encoding a Na(+),K(+)/H(+) antiporter, composed of a transmembrane domain and a large carboxyl-terminal tail, which has been related to cation detoxification processes. Expression of either the powerful Saccharomyces cerevisiae Ena1 Na(+)/H… CONTINUE READING