A screen of approved drugs and molecular probes identifies therapeutics with anti-Ebolavirus activity

@article{Johansen2015ASO,
  title={A screen of approved drugs and molecular probes identifies therapeutics with anti-Ebolavirus activity},
  author={Lisa Johansen and Lisa Evans Dewald and Charles J. Shoemaker and Benjamin G. Hoffstrom and Calli M. Lear-Rooney and Andrea Stossel and Elizabeth Nelson and Sue Ellen Delos and James A. Simmons and Jill M. Grenier and Laura T. Pierce and Hassan Pajouhesh and Joseph Lehar and Lisa E. Hensley and Pamela J. Glass and Judith M White and Gene Garrard Olinger},
  journal={Science Translational Medicine},
  year={2015},
  volume={7},
  pages={290ra89-290ra89}
}
Currently, no approved therapeutics exist to treat or prevent infections induced by ebolaviruses, and recent events have demonstrated an urgent need for rapid discovery of new treatments. Repurposing approved drugs for emerging infections remains a critical resource for potential antiviral therapies. We tested ~2600 approved drugs and molecular probes in an in vitro infection assay using the type species, Zaire ebolavirus. Selective antiviral activity was found for 80 U.S. Food and Drug… CONTINUE READING
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