A screen for genes that influence fibroblast growth factor signal transduction in Drosophila.

  title={A screen for genes that influence fibroblast growth factor signal transduction in Drosophila.},
  author={Min Yan Zhu and Robert Wilson and Maria Leptin},
  volume={170 2},
The misexpression of an activated form of the FGF receptor (FGFR) Breathless in conjunction with downstream-of-FGF-receptor (Dof), an essential signaling molecule of the FGF pathway, in the Drosophila eye imaginal discs impairs eye development and results in a rough eye phenotype. We used this phenotype in a gain-of-function screen to search for modifiers of FGF signaling. We identified 50 EP stocks with insertions defining at least 35 genes that affect the rough eye phenotype. Among these… CONTINUE READING

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