A scientific revolution?

@article{Bussard2005ASR,
  title={A scientific revolution?},
  author={A. Bussard},
  journal={EMBO reports},
  year={2005},
  volume={6}
}
  • A. Bussard
  • Published 2005
  • Biology, Medicine
  • EMBO reports
Science, Thomas Kuhn argued in The Structure of Scientific Revolutions (1962), proceeds at two different paces. One is what he called “normal science”, which professionals, the general public, the press and politicians generally understand as “research firmly based upon one or more past achievements that some particular scientific community acknowledges for a time as supplying the foundation for its further practice.” This stepwise progression towards a better understanding of Nature, by… Expand
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References

SHOWING 1-10 OF 34 REFERENCES
The Structure of Scientific Revolutions
A good book may have the power to change the way we see the world, but a great book actually becomes part of our daily consciousness, pervading our thinking to the point that we take it for granted,Expand
The End of History and the Last Man
20th anniversary edition of "The End of History and the Last Man", a landmark of political philosophy by Francis Fukuyama, author of "The Origins of Political Order". With the fall of Berlin Wall inExpand
Unended Quest: An Intellectual Autobiography
Although most of us know the date and place of our birth...few know when and how their intellectual life began. .. Here one of the greatest thinkers of our age recalls the landmarks of hisExpand
Structural insights into a yeast prion illuminate nucleation and strain diversity
TLDR
The nature of Sup35's cooperatively folded amyloid core is determined, and this information is used to investigate central questions in prion biology and have broad implications for other amyloids. Expand
Mutation processes at the protein level: is Lamarck back?
TLDR
The prion model puts in doubt the notion that cloned animals are genetically identical to their genome donors, and suggests that genome sequence would not provide a complete information about the genetic makeup of an organism. Expand
A yeast prion provides a mechanism for genetic variation and phenotypic diversity
TLDR
It is proposed that the epigenetic and metastable nature of [PSI+] inheritance allows yeast cells to exploit pre-existing genetic variation to thrive in fluctuating environments and the capacity of [Psi+] to convert previously neutral genetic variations to a non-neutral state may facilitate the evolution of new traits. Expand
Ψ, A cytoplasmic suppressor of super-suppressor in yeast
TLDR
During the course of studies on spontaneous inter-allelic reversions during vegetative growth in yeast, a number of revertants were recovered whose behaviour showed that they were due to genetically controlled suppression of one of the alleles in the diploid. Expand
Prions as adaptive conduits of memory and inheritance
Changes in protein conformation drive most biological processes, but none have seized the imagination of scientists and the public alike as have the self-replicating conformations of prions. PrionsExpand
Chemistry and Biology of Proteins
  • F. Haurowitz
  • Chemistry
  • The Yale Journal of Biology and Medicine
  • 1951
forth effort at the proper times. Immediately following is a chapter entitled "The Psychology of Labor" in which the sensations of the different stages are described, as well as the actual mechanicsExpand
A Neuronal Isoform of the Aplysia CPEB Has Prion-Like Properties
TLDR
It is hypothesized that conversion of CPEB to a prion-like state in stimulated synapses helps to maintain long-term synaptic changes associated with memory storage, and is the dominant, self-perpetuating prions-like form that has the greatest capacity to stimulate translation of C PEB-regulated mRNA. Expand
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