A schizophrenic patient with an arrhythmic circadian rest-activity cycle.

@article{WirzJustice1997ASP,
  title={A schizophrenic patient with an arrhythmic circadian rest-activity cycle.},
  author={Anna M Wirz-Justice and Christian Cajochen and P E Nussbaum},
  journal={Psychiatry research},
  year={1997},
  volume={73 1-2},
  pages={
          83-90
        }
}
A haloperidol-treated patient with chronic schizophrenia had a near-arrhythmic circadian rest-activity cycle, whereas rhythms of 6-sulphatoxy-melatonin and core body temperature were of normal amplitude and phase-advanced. Sleep electroencephalography measured throughout a 31-h 'constant-bedrest' protocol revealed a phase-delayed sleep-wake propensity cycle, low sleep continuity (ultradian 'bouts'), and very little slow-wave sleep and slow-wave activity (0.75-4.5 Hz). Switching treatment to the… CONTINUE READING

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