A scalable formulation for engineering combination therapies for evolutionary dynamics of disease

Abstract

It has been shown that optimal controller synthesis for positive systems can be formulated as a linear program. Leveraging these results, we propose a scalable iterative algorithm for the systematic design of sparse, small gain feedback strategies that stabilize the evolutionary dynamics of a generic disease model. We achieve the desired feedback structure… (More)
DOI: 10.1109/ACC.2014.6859452

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