A rule of seven in Watson-Crick base pairing of mismatched sequences

@inproceedings{Cisse2012ARO,
  title={A rule of seven in Watson-Crick base pairing of mismatched sequences},
  author={Ibrahim I. Cisse and Hajin J. Kim and Taekjip Ha},
  booktitle={Nature Structural &Molecular Biology},
  year={2012}
}
Sequence recognition through base-pairing is essential for DNA repair and gene regulation, but the basic rules governing this process remain elusive. In particular, the kinetics of annealing between two imperfectly matched strands is not well characterized, despite its potential importance in nucleic acid–based biotechnologies and gene silencing. Here we use single-molecule fluorescence to visualize the multiple annealing and melting reactions of two untethered strands inside a porous vesicle… CONTINUE READING
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