A rugged energy landscape mechanism for trapping of transmembrane receptors during endocytosis.

@article{Licht2003ARE,
  title={A rugged energy landscape mechanism for trapping of transmembrane receptors during endocytosis.},
  author={Stuart S Licht and Alois Sonnleitner and Shimon Weiss and Peter G. Schultz},
  journal={Biochemistry},
  year={2003},
  volume={42 10},
  pages={2916-25}
}
Efficient clathrin-mediated endocytosis of transmembrane receptors requires that clathrin-coated pits retain the receptors long enough to allow vesicle formation and internalization. In many cases, however, the receptors can exhibit mean lifetimes in coated pits much shorter than the lifetime of the pit at the plasma membrane. A rugged energy landscape for binding, which produces a broad distribution of residence times, ensures a significant probability of times much greater than the mean and… CONTINUE READING

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