A roller coaster ride with the mitotic cyclins.

@article{Fung2005ARC,
  title={A roller coaster ride with the mitotic cyclins.},
  author={T. Fung and R. Poon},
  journal={Seminars in cell \& developmental biology},
  year={2005},
  volume={16 3},
  pages={
          335-42
        }
}
  • T. Fung, R. Poon
  • Published 2005
  • Biology, Medicine
  • Seminars in cell & developmental biology
Cyclins are discovered as proteins that accumulate progressively through interphase and disappear abruptly at mitosis during each cell cycle. In mammalian cells, cyclin A accumulates from late G1 phase and is destroyed before metaphase, and cyclin B is destroyed slightly later at anaphase. The abundance of the mitotic cyclins is mainly regulated at the levels of transcription and proteolysis. Transcription is stimulated and repressed by several transcription factors, including B-MYB, E2F, FOXM1… Expand
APOLLON Protein Promotes Early Mitotic CYCLIN A Degradation Independent of the Spindle Assembly Checkpoint*
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Role of cyclin B1 levels in DNA damage and DNA damage-induced senescence.
The Kinetics of G2 and M Transitions Regulated by B Cyclins
How protein kinases co-ordinate mitosis in animal cells.
  • Hoi Tang Ma, R. Poon
  • Biology, Medicine
  • The Biochemical journal
  • 2011
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References

SHOWING 1-10 OF 95 REFERENCES
Cyclin A in cell cycle control and cancer
Cell cycle-regulated proteolysis of mitotic target proteins.
Phosphorylation of the cyclosome is required for its stimulation by Fizzy/cdc20.
Securin and B-cyclin/CDK are the only essential targets of the APC
...
1
2
3
4
5
...