A role of topoisomerase II in linking DNA replication to chromosome condensation

@article{Cuvier2003ARO,
  title={A role of topoisomerase II in linking DNA replication to chromosome condensation},
  author={Olivier Cuvier and Tatsuya Hirano},
  journal={The Journal of Cell Biology},
  year={2003},
  volume={160},
  pages={645 - 655}
}
The condensin complex and topoisomerase II (topo II) have different biochemical activities in vitro, and both are required for mitotic chromosome condensation. We have used Xenopus egg extracts to investigate the functional interplay between condensin and topo II in chromosome condensation. When unreplicated chromatin is directly converted into chromosomes with single chromatids, the two proteins must function together, although they are independently targeted to chromosomes. In contrast, the… CONTINUE READING