A role of the latent TGF-beta 1-binding protein in the assembly and secretion of TGF-beta 1.

@article{Miyazono1991ARO,
  title={A role of the latent TGF-beta 1-binding protein in the assembly and secretion of TGF-beta 1.},
  author={Kohei Miyazono and Anita Olofsson and P Colosetti and C H Heldin},
  journal={The EMBO journal},
  year={1991},
  volume={10 5},
  pages={1091-101}
}
Transforming growth factor-beta 1 (TGF-beta 1) is synthesized as latent complexes with high molecular weights. The large latent complex of TGF-beta 1 in platelets is composed of three components, i.e. the mature TGF-beta 1, which is non-covalently associated with a disulphide-bonded complex of the N-terminal remnant of the TGF-beta 1 precursor (TGF-beta 1-latency associated peptide) and the latent TGF-beta 1 binding protein (LTBP). The TGF-beta 1-latency associated peptide is sufficient for the… CONTINUE READING
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