A role of the double-stranded RNA-binding protein PACT in mouse ear development and hearing.

@article{Rowe2006ARO,
  title={A role of the double-stranded RNA-binding protein PACT in mouse ear development and hearing.},
  author={Theresa M Rowe and Mark Douglas Rizzi and Keiko Hirose and Gregory A. Peters and Ganes C Sen},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2006},
  volume={103 15},
  pages={5823-8}
}
To determine the physiological functions of the mammalian double-stranded RNA-binding protein PACT, the single-copy mouse Pact gene was disrupted and expression of the protein was completely ablated. The most notable phenotypes of the Pact(-/-) mouse were reduced size and severe microtia. As a result of the congenital abnormality of both outer and middle ears, these mice were hearing impaired. In situ hybridization revealed that PACT mRNA was expressed in specific regions of all three parts of… CONTINUE READING

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A role of the double-stranded RNA-binding protein PACT in mouse ear development and hearing

  • M. Rowe, Mark Rizzi, Keiko Hirose, Gregory A. Peters, C Ganes
  • (received for review September
  • 2006

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